IPF pathophysiology

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    • Lung tissue becomes scarred, thicker and less elastic.
    • Less available lung area for gas exchange in the scarred areas of the alveoli.
    • Lungs lose their ability to transfer oxygen into the bloodstream.
    • Scarring typically progresses making it more difficult to breathe.
    • Breathlessness is worse on even slight exertion.
    • In the absence of other factors such as infection,  worsening breathlessness is a indicator of poor prognosis.